Phenotype report - Young-onset hypertension (HGVPM655)
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Phenotype summary
GWAS Central identifier HGVPM655
Phenotype Young-onset hypertension
Used in Study GWAS of young-onset hypertension in the Han Chinese population of Taiwan (HGVST379)
Description Inclusion criteria for YOH patients were defined as follows: (1) a systolic blood pressure (SBP) >= 140 mmHg and/or diastolic blood pressure (DBP) >= 90 mmHg over a 2-month period or, for those who were on anti-hypertensive medication, SBP/DBP >= 120/80 mmHg at two consecutive visits over a 2-month period; (2) an initial diagnosis of hypertension between 20 and 51 years of age; (3) no secondary causes of hypertension (such as chronic renal disease, renal arterial stenosis, primary aldosteronism, coarctation of the aorta, thyroid disorders, Cushing's syndrome and pheochromocytoma), which were ruled out through extensive clinical investigations (including blood chemistry, renal function tests, endocrine procedures and abdominal sonogram); (4) a fasting glucose level < 126 mg/dl and no previous diagnosis of diabetes mellitus; (5) a body mass index < 35 kg/m2; (6) having both sides of parents and grandparents identifying themselves as Han Chinese; (7) being a legal resident of Taiwan. Standard protocols for blood pressure measurements established by the Nutrition and Health Survey in Taiwan were followed by all above studies. Blood pressure was measured three times with two consecutive pulse measurements in between using the Omega 1400 NBP (Invivo Research Laboratories Inc., Orlando, FL, USA). The average of the last two blood pressure measurements was used to confirm the hypertension status. In addition, personal interviews administered by trained nurses ascertained information on socio-demographics, lifestyle and personal habits (smoking, drinking and physical activity) and medical history and medications. For each eligible subject, 17.5 ml of venous blood from an antecubital vein was drawn into a Vacutainer(R) tube (BD, Franklin Lakes, NJ, USA) for clinical chemistry, and 5 ml was drawn into a sodium citrate-containing Monovette tube (Sarstedt AG and Co., Postfach, Nümbrecht, Germany) for DNA extraction.
Variable type Not supplied
Variable unit Not supplied
Related links Not supplied
Phenotype annotation MeSH: Hypertension (D006973)link
HPO: Hypertension (HP:0000822)link
Phenotypes inferred from OMIM info Not available
Method details
No phenotype method details are currently available in GWAS Central.