Study Report - GWAS of ischemic stroke (HGVST14)
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| Identifier | HGVST14 | |||||||||||||||
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| Study name | GWAS of ischemic stroke | |||||||||||||||
| Total p-values imported | 786,560 | |||||||||||||||
| Phenotype(s) tested | Ischemic stroke |
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| Study design | Case and control | |||||||||||||||
| Genotype platforms |
HumanHap300 Illumina Infinium Human-1 | |||||||||||||||
| Abstract | Summary-level data and analysis results from the National Institute of Neurological Disorders and Stroke (NINDS) Ischemic Stroke Genetics Study (ISGS) imported from dbGaP. BACKGROUND: Despite evidence of a genetic role in stroke, the identification of common genetic risk factors for this devastating disorder remains problematic. We aimed to identify any common genetic variability exerting a moderate to large effect on risk of ischaemic stroke, and to generate publicly available genome-wide genotype data to facilitate others doing the same. METHODS: We applied a genome-wide high-density single-nucleotide-polymorphism (SNP) genotyping approach to a cohort of samples with and without ischaemic stroke (n=278 and 275, respectively), and did an association analysis adjusted for known confounders in a final cohort of 249 cases and 268 controls. More than 400,000 unique SNPs were assayed. FINDINGS: We produced more than 200 million genotypes in 553 unique participants. The raw genotypes of all the controls have been posted publicly in a previous study of Parkinson's disease. From this effort, results of genotype and allele association tests have been publicly posted for 88% of stroke patients who provided proper consent for public release. Preliminary analysis of these data did not reveal any single locus conferring a large effect on risk for ischaemic stroke. INTERPRETATION: The data generated here comprise the first phase of a genome-wide association analysis in patients with stroke. Release of phase I results generated in these publicly available samples from each consenting individual makes this dataset a valuable resource for data-mining and augmentation | |||||||||||||||
| Submission information |
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Author communication  |
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| Related links |
dbGaP - Ischemic Stroke Genetics Study (ISGS) |
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| Background | Not supplied | |||||||||||||||
| Objectives | Not supplied | |||||||||||||||
| Key results | Not supplied | |||||||||||||||
| Conclusions | Not supplied | |||||||||||||||
| Reason for study size | Not supplied | |||||||||||||||
| Study power | Not supplied | |||||||||||||||
| Sources of bias | Not supplied | |||||||||||||||
| Limitations | Not supplied | |||||||||||||||
| Acknowledgements | Not supplied | |||||||||||||||
| Related citations |
Matarin M, Brown WM, Scholz S et al.
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol. 2007 May;6(5):414-20 |
